Publications
https://scholar.google.com/citations?user=yvIsuacAAAAJ&hl=es&oi=ao
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In Situ Single-Cell Bacterial Imaging Provides Mechanistic Insight into the Photodynamic Action of Photosensitizer-Loaded Hydrogels
Ingrid V. Ortega, Tuğçe Şener Raman, Agnes Schulze, Cristina Flors
ACS Applied Materials and Interfaces, 2024, 16, 5, 5677 -
Min oscillations in bacteria as real-time reporter of environmental challenges at the single-cell level
Ingrid V. Ortega, Felipe Viela, Cristina Flors
Open Biology, 2023, 13: 230020 -
Real-Time Imaging of the Mechanobactericidal Action of Colloidal Nanomaterials and Nanostructured Topographies
Felipe Viela, Ingrid V. Ortega, Jaime J. Hernández, Isabel Rodríguez, Sara Moreno-Da Silva, Alejandro López-Moreno, Emilio M. Pérez, Cristina Flors
Small Science, 2023, 2300002 - Activatable iodinated BODIPYs for selective imaging and photodynamic disruption of amyloid structures in pathogenic bacterial biofilms J. Torra, T. Sawazaki, P. Bondia, S. Nonell, M. Kanai, Y. Sohma, C. Flors
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Versatile Near-Infrared Super-Resolution Imaging of Amyloid Fibrils with the Fluorogenic Probe CRANAD-2
J. Torra, F. Viela, D. Megias, B. Sot, C. Flors
Chemistry- A European Journal, 2022, 28, e202200026 - Min Oscillations as Real-time Reporter of Sublethal Effects in Photodynamic Treatment of Bacteria I. V. Ortega, J. Torra, C. Flors
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Boosting the inactivation of bacterial biofilms by photodynamic targeting of matrix structures with Thioflavin T
P. Bondia, C. Flors, J. Torra
Chemical Communications, 2021,57, 8648 -
9-Aryl-phenalenones: Bioinspired thermally reversible photochromic compounds for photoswitching applications in the pico-to milliseconds range. R. Bresolí-Obach, W. A. Massad, A. Abudulimu, L. Lüer, C. Flors, J. G. Luis, L. I. Rosquete, Teresa A. Grillo, O. Anamimoghadam, G. Bucher, S. Nonell, Dyes and Pigments, 2021,186, 109060
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Long-term STED imaging of amyloid fibers with exchangeable Thioflavin T. J. Torra, P. Bondia, S. Gutierrez-Erlandsson, B. Sot, C. Flors, Nanoscale, 2020,12, 15050-15053
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Mechanically Induced Bacterial Death Imaged in Real Time: A Simultaneous Nanoindentation and Fluorescence Microscopy Study. A. del Valle, J. Torra, P. Bondia, C. M. Tone, P. Pedraz, V. Vadillo-Rodríguez, C. Flors, ACS Applied Materials & Interfaces 2020, 12 (28), 31235–31241
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Nanoscale view of amyloid photodynamic damage. P. Bondia, J. Torra, C. M. Tone, T. Sawazaki, A. del Valle, B. Sot, S. Nonell, M. Kanai, Y. Sohma, C. Flors, J. Am Chem. Soc. 2020, 142, 922
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Tailing miniSOG: structural bases of the complex photophysics of a flavin-binding singlet oxygen photosensitizing protein. Joaquim Torra, Céline Lafaye, Luca Signor, Sylvain Aumonier, Cristina Flors, Xiaokun Shu, Santi Nonell, Guillaume Gotthard, Antoine Royant, Sci. Rep. 2019, 9, 2428
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Linear assembly of lead bromide-based nanoparticles inside lead (II) polymers prepared by mixing the precursors of both the nanoparticle and the polymer. S. Gonzalez-Carrero, L. Bareño, E. Debroye, C. Martin, P. Bondia, C. Flors, R. E Galian, J. Hofkens, J. Pérez-Prieto, Chem. Commun. 2019, 55, 2968-2971
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Mechanics of Virus-like Particles Labeled with Green Fluorescent Protein. Johann Mertens, Patricia Bondia, CarolinaAllende-Ballestero, José L. Carrascosa, Cristina Flors, José R. Castón, Biophys. J. 2018, 115(8),1561
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Singlet Oxygen: Chemistry, Applications and Challenges Ahead. Cristina Flors, Axel G. Griesbeck, Georgios Vassilikogiannakis, ChemPhotoChem 2018, 2(7) 510
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Fluorescent Flavoprotein Heterodimers: Combining Photostability with Singlet Oxygen Generation. Alberto Rodríguez‐Pulido, Joaquim Torra, Sara H. Mejías, Aitziber L. Cortajarena, Rubén Ruiz‐González , Santi Nonell, Cristina Flors, ChemPhotoChem 2018, 2(7) 571
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Dominik Wöll and Cristina Flors, Super-resolution Fluorescence Imaging for Materials Science, Small Methods 2017, 1, 1700191 doi/10.1002/smtd.201700191/abstract
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Correlative Super-Resolution Fluorescence Imaging and Atomic Force Microscopy for the Characterization of Biological Samples, P. Bondia,S. Casado, C. Flors, Methods in Molecular Biology 2017, 1663, 105-113
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Super-resolution Fluorescence Imaging for Materials Science, D. Wöll, C. Flors, Small Methods 2017, 1(10), 1700191
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Hybrid nanoscopy of hybrid nanomaterials, P. Bondia, R. Jurado, S. Casado, J. M. Domínguez-Vera, N. Gálvez, C. Flors, Small 2017, 13(17), 1604128.
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Photoswitching-Enabled Contrast Enhancement in Light Sheet Fluorescence Microscopy, T. Vettenburg, A. Corral, A. Rodríguez-Pulido, C. Flors, J. Ripoll, ACS Photonics 2017, 4(3), 424-428
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Real-time imaging of photodynamic action in bacteria, A. Gollmer, A. Felgentraeger, T. Maisch, C. Flors, J. Biophoton. 2017, 10(2), 264-270
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Assessing the potential of photosensitizing flavoproteins as tags for correlative microscopy, A. Rodríguez-Pulido, A. L. Cortajarena, J. Torra, R. Ruiz-González, S. Nonell and C. Flors, Chem. Commun., 2016, 52, 8405-8408
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Apoferritin Fibers: a New Template for 1D Fluorescent Hybrid Nanostructures, R. Jurado, F. Castello, P. Bondia, S. Casado, C. Flors, R. Cuesta, J. M. Domínguez-Vera, Á. Orte and N. Gálvez, Nanoscale 2016, 8, 9648-9656
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Antibacterial Activity of DNA-Stabilized Silver Nanoclusters Tuned by Oligonucleotide Sequence, S. Javani, R. Lorca, A. Latorre, C. Flors, A. L. Cortajarena, and Á. Somoza, ACS Appl. Mater. Interfaces 2016, 8 (16), pp 10147–10154
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Biologically controlled synthesis and assembly of magnetite nanoparticles, M. Bennet, L. Bertinetti, R. K. Neely, A. Schertel, A. Körnig, C. Flors, F. D. Müller, D. Schüler, S. Klumpp, D. Faivre, Faraday Discuss 2015, 18, 71-83.
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β-Phenyl quenching of 9-phenylphenalenones: a novel photocyclisation reaction with biological implications, G. Bucher, R. Bresolí-Obach, C. Brosa, C. Flors, J. G. Luis, T. A. Grillo, S. Nonell, Phys. Chem. Chem. Phys. 2014,16, 18813-18820
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Correlative Atomic Force Microscopy and Localization-Based Super-Resolution Microscopy: Revealing Labelling and Image Reconstruction Artefacts, A. Monserrate, S. Casado, C. Flors, ChemPhysChem 2014, 5, 647–650
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Singlet Oxygen Generation by the Genetically Encoded Tag miniSOG, R. Ruiz-González, A. L. Cortajarena, S. H. Mejias, M. Agut, S. Nonell, C. Flors, J. Am. Chem. Soc., 2013, 135 (26), 9564–9567
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Super-resolution fluorescence imaging of directly labelled DNA: from microscopy standards to living cells, C. Flors, J. Microscopy 2013, 251, 1-4
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Naphthoxanthenyl, a New Stable Phenalenyl Type Radical Stabilized by Electronic Effects, O. Anamimoghadam, M. D. Symes, C. Busche, D.-L. Long, S. T. Caldwell, C. Flors, S. Nonell, L. Cronin, G. Bucher, Org. Lett., 2013, 15 (12), 2970–2973
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Single-molecule imaging at high hydrostatic pressure, H. Vass, S. L. Black, C. Flors, D. Lloyd, F. B. Ward, R. J. Allen, Appl. Phys. Lett. 2013, 102, 154103
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Fluorescent proteins as singlet oxygen photosensitizers: mechanistic studies in photodynamic inactivation of bacteria, R. Ruiz-González, J. H. White, A. L. Cortajarena, M. Agut, S. Nonell, C. Flors, Proc. SPIE 8596, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 859609 (2013)
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A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen, R. Ruiz-González, J. H. White, M. Agut, S. Nonell, C. Flors, Photochem. Photobiol. Sci., 2012,11, 1411-1413
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Reversible Fluorescence Photoswitching in DNA, D. A. Smith, P. Holliger, C. Flors, J. Phys. Chem. B, 2012, 116 (34), 10290–10293
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Super-resolution fluorescence microscopy as a tool to study the nanoscale organization of chromosomes, C. Flors, W. C. Earnshaw, Curr. Op. Chem. Biol, 2011, 15, 838–844
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FIT for Purpose: PNA-Based Probes Enable mRNA Imaging in Living Cells, J. Tilsner, C. Flors, ChemBioChem 2011, 12, 1007-9
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DNA and Chromatin Imaging with Super-Resolution Fluorescence Microscopy Based on Single-Molecule Localization, C. Flors, Biopolymers 2011, 95, 290-7
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Quantification of Photosensitized Singlet Oxygen Production by a Fluorescent Protein, X. Ragàs, L. P. Cooper, J. H. White, S. Nonell, C. Flors, ChemPhysChem 2011, 12, 161-5
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Singlet oxygen photosensitisation by GFP mutants: oxygen accessibility to the chromophore, A. Jiménez-Banzo, X. Ragàs, S. Abbruzzetti, C. Viappiani, B. Campanini, C. Flors, S. Nonell, Photochem. Photobiol. Sci., 2010,9, 1336-1341
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A super-resolution map of the vertebrate kinetochore, S. A. Ribeiro, P. Vagnarelli, Y. Dong, T. Hori, B. F. McEwen, T. Fukagawa, C. Flors, W. C. Earnshaw, PNAS 2010, 107, 10484–10489
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Photoswitching of monomeric and dimeric DNA-intercalating cyanine dyes for super-resolution microscopy applications, C. Flors, Photochem. Photobiol. Sci., 2010,9, 643-648
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Super-Resolution Imaging of DNA Labelled with Intercalating Dyes, C. Flors, C. N. J. Ravarani, D. T. F. Dryden, ChemPhysChem 2009, 10, 2201–2204
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Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis, P. Morin, C. Flors, M. F. Olson, Eur. J. Cell Biol 2009, 88, 495–507
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Nonlinear optical properties of photoswitchable fluorescent proteins, I. Asselberghs, C. Flors, E. De Meulenaere, B. Champagne, J. Vanderleyden, K. Clays, Proc. SPIE 7403, Nanobiosystems: Processing, Characterization, and Applications II, 74030P (2009)
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Second-Harmonic Generation in GFP-like Proteins, I. Asselberghs, C. Flors, L. Ferrighi, E. Botek, B. Champagne, H. Mizuno, R. Ando, A. Miyawaki, J. Hofkens, M. Van der Auweraer, K. Clays, J. Am. Chem. Soc., 2008, 130 (46), pp 15713–15719
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How is cis-trans isomerization controlled in Dronpa mutants? A replica exchange molecular dynamics study, S. L. C. Moors , S. Michielssens, C. Flors, P. Dedecker, J. Hofkens, A. Ceulemans, J. Chem. Theory Comput., 2008, 4 (6), pp 1012–1020
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Dark states in monomeric red fluorescent proteins studied by fluorescence correlation and single molecule spectroscopy, J. Hendrix, C. Flors, P. Dedecker, J. Hofkens, Y. Engelborghs, Biophys. J. 2008, 94, p4103–4113
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Singlet oxygen photosensitization by EGFP and its chromophore HBDI, A. Jiménez-Banzo, S. Nonell, J. Hofkens, C. Flors, Biophys. J. 2008, 94, 168–172
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Subdiffraction imaging through the selective donut-mode depletion of thermally stable photoswitchable fluorophores: Numerical analysis and application to the fluorescent protein Dronpa, P. Dedecker , J. Hotta ,C. Flors, M. Sliwa ,H. Uji-i ,M. B. J. Roeffaers, R. Ando, H. Mizuno, A. Miyawaki, J. Hofkens, J. Am. Chem. Soc., 2007, 129 (51), pp 16132–16141
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A stroboscopic approach for fast photoactivation-localization microscopy with Dronpa mutants, C. Flors, J. Hotta, H. Uji-i ,P. Dedecker, R. Ando, H. Mizuno, A. Miyawaki , J. Hofkens, J. Am. Chem. Soc., 2007, 129 (45), pp 13970–13977
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3D nanoscopy: Bringing biological nanostructures into sharp focus, P. Dedecker, C. Flors, J. Hotta, H. Uji-i, J. Hofkens, Angewandte Chem. Int. Ed. 2007, 46, 8330–8332
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Single perylene diimide dendrimers as single-photon sources, M. Sliwa, C. Flors, I. Oesterling, J. Hotta, K. Müllen, F. C. De Schryver, J. Hofkens, J. Phys.: Condens. Matter 19 445004
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Highlighted generation of fluorescence signals using simultaneous two-color irradiation on Dronpa mutants, R. Ando, C. Flors, H. Mizuno, J. Hofkens, A. Miyawaki, Biophys. J. 2007, 92, L97–L99
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Ultrafast excited-state dynamics of the photoswitchable protein dronpa, E. Fron, C. Flors, G. Schweitzer, S. Habuchi, H. Mizuno, R. Ando, F. C. De Schryver, A. Miyawaki, J. Hofkens, J. Am. Chem. Soc., 2007, 129 (16), pp 4870–4871
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Energy and electron transfer in ethynylene bridged perylene diimide multichromophores, C. Flors ,I. Oesterling, T. Schnitzler, E. Fron, G. Schweitzer, M. Sliwa, A. Herrmann, M. van der Auweraer, F. C. de Schryver, K. Müllen, J. Hofkens, J. Phys. Chem. C, 2007, 111 (12), pp 4861–4870
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Photo-induced protonation/deprotonation in the GFP-like fluorescent protein Dronpa: mechanism responsible for the reversible photoswitching, S. Habuchi, P. Dedecker, J. Hotta, C. Flors, R. Ando, H. Mizuno, A. Miyawaki, J. Hofkens, Photochem. Photobiol. Sci., 2006,5, 567-576
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Photoconversion in the red fluorescent protein from the sea anemone Entacmaea quadricolor: Is cis-trans isomerization involved?, D. Loos , S. Habuchi, C. Flors, J. Hotta, J. Wiedenmann, G. U. Nienhaus, J. Hofkens, J. Am. Chem. Soc., 2006, 128 (19), pp 6270–6271
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Solvent and pH dependent fluorescent properties of a dimethylaminostyryl borondipyrromethene dye in solution, M. Baruah, W. Qin, C. Flors , J. Hofkens, R. A. L. Vallée , D. Beljonne , M. Van der Auweraer, W. M. De Borggraeve, N. Boens, J. Phys. Chem. A, 2006, 110 (18), pp 5998–6009
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Light and singlet oxygen in plant defense against pathogens: Phototoxic phenalenone phytoalexins, C. Flors, S. Nonell, Acc. Chem. Res., 2006, 39 (5), pp 293–300
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Imaging the production of singlet oxygen in vivo using a new fluorescent sensor, Singlet Oxygen Sensor Green (R), C. Flors, M. J Fryer, J. Waring, B. Reeder, U. Bechtold, P. M. Mullineaux, S. Nonell, M. T. Wilson, N. R Baker, J. Exp. Bot. (2006) 57 (8): 1725-1734.
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Phototoxic phytoalexins. Processes that compete with the photosensitized production of singlet oxygen by 9-phenylphenalenones, C. Flors, P. R. Ogilby, J. G. Luis, T. A. Grillo, L. R. Izquierdo, P-L Gentili, L. Bussotti, S. Nonell, Photochem. Photobiol. 2006, 82, 95–103
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Photochemistry of phytoalexins containing phenalenone-like chromophores: Photophysics and singlet oxygen photosensitizing properties of the plant oxoaporphine alkaloid oxoglaucine, C. Flors, C. Prat, R. Suau, F. Nájera, S. Nonell, Photochem. Photobiol. 2005, 81, 120-124
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Light- and singlet oxygen-mediated antifungal activity of phenylphenalenone phytoalexins, A. Lazzaro, M. Corominas, C. Martí, C. Flors, L. R. Izquierdo, T. A. Grillo, J. G. Luis, S. Nonell, Photochem. Photobiol. Sci., 2004,3, 706-710
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Radical species derived from phenalenone: characterization and role of upper excited states, C. Flors, S. Nonell, J. Photochem. Photobiol. A. Chem. 2004, 163, 9-12
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On the phosphorescence of 1H-phenalen-1-one, C. Flors, S. Nonell, Helv. Chim. Acta 2001, 84, 2533–2539
Sensors and Actuators B: Chemical, 2022, 371, 132475
ACS Infectious Diseases, 2022, 8, 86