MULTIFUN MultiFunctional Nanotechnology for Selective Detection and Treatment of Cancer

Prof. Rodolfo Miranda, Dr.Francisco Terán, Dr.Aitziber López-Cortajarena & Dr. A. Somoza

Funding : FP7-NMP-2010-LARGE-4 nº 262943-2

Duration: 2011 - 2015

60 months

The aim of the MultiFun consortium is to develop and validate a novel and minimallyinvasive nanotechnology system to improve cancer diagnosis and treatment. MultiFun nanotechnology is based on multifunctionalised magnetic nanoparticles (MNP) to selectively target and eliminate breast and pancreatic cancer (stem) cells. The improved magnetic features of the MultiFun MNP will lead to medical applications such as contrast agents and magnetic heating inductors. Moreover, MNP can be functionalised with ligands in order to facilitate tumour diagnosis by MRI. Targeting peptides and antibodies will be employed against cancer (stem) cells leading to early cancer detection, an increase of the effectiveness and reducing side effects. The same MNP will be used simultaneously as functional nanocarriers and heating inductors in order to provide a multimodal therapeutic modality. The synergistic effects of drugs, peptides, small RNAs and heat will be evaluated to determine the effectiveness of different therapeutic combinations.

THERAGNOSIS: MRI detection + Multimodal Therapeutic Approach
Multimodal Therapeutic Approach

http://nanociencia.imdea.org/images/nanociencia/scientific_reports/Scientific-Report-2014.pdf